Select Publications

*Shaban D, Najm N, Droin L, Nijnik A. Hematopoietic Stem Cell Fates and the Cellular Hierarchy of Mammalian Hematopoiesis: from Transplantation Models to New Insights from in Situ Analyses. Stem Cell Rev Rep. 2024.

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*Liang Y, Wang H, Seija N, Lin Y, Tung LT, Di Noia JM, Langlais D, Nijnik A. B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1. Front Immunol. 2024.

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*Mousa M, *Liang Y, Tung LT, Wang H, Krawczyk C, Langlais D, Nijnik A. Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation. Immunology. 2024.

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*Wang H, Langlais D, Nijnik A. Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis. Int J Biochem Cell Biol. 2023.

*Liang, Y., Bhatt, G., Tung, L.T., Wang, HC, Kim, J.E, Mousa. M, Plackoska. V, Illes. K, Georges, A.A, Gros. P, Henneman. L, Huijbers, I.J, Nagar, B, Nijnik. A. Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development. Scientific Reports. 2023.

*Plackoska V, *Shaban D, Nijnik A. Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression. Frontiers in Immunology. 2022.

*Tung LT, Wang H, Belle JI, Petrov JC, Langlais D, Nijnik A. p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress. Cell Death Dis. 2021 

*Belle JI, *Wang HC, Fiore A, Petrov JC, Lin YH, Feng CH, Tung LT, Nguyen TT, Campeau PM, Brunet T, Leszinski GS, Gros P, Langlais P, Nijnik A. MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells to Prevent Hematopoietic Dysfunction. JCI Insight 2020.
 
*Fiore A, Liang Y, Lin YH, Tung J, Wang HC, Langlais D, Nijnik A. Deubiquitinase MYSM1 in the hematopoietic system and beyond: a current review. Int J Mol Sci. 2020.
 
*Lin Y, Forster M, Liang Y, Wang HC, Robert F, Langlais D, Pelletier J, Clare S, Nijnik A. USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. Exp Hematol. 2019.
 
Kaufmann E, Dunn JL, Sanz J, Khan N, Pacis A, Tzelepis F, Pernet E, Dumaine A, Ahmed E, Belle JI, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi M. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018.
 
*Förster M, Boora R, Petrov J, Fodil N, Albanese I, Kim J, Gros P, Nijnik A. A role for the histone deubiquitinase MYSM1 in maintenance of CD8 T cells. Immunology. 2017.
 
*Förster M, Farrington K, Petrov JC, Belle J, Mindt B, Witalis M, Duerr CU, Fritz JH, Nijnik A. MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response. J Leukoc Biol. 2017.
 
*Petrov JC, Nijnik A. MYSM1 expression in the bone marrow niche is not essential for hematopoietic maintenance. Exp Hematol. 2017.
 
You L, Li L, Zou J, Belle J, Nijnik A, Wang E, Yang X. BRPF1 is essential for development of fetal hematopoietic stem cells. J Clin Invest. 2016.
 
*Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A. Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death Differ. 2016.
 
*Förster M, Belle JI, Petrov JC, Ryder  EJ, Clare S, Nijnik A. Deubiquitinase MYSM1 is Essential for Normal Fetal Liver Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow. Stem Cells Dev. 2015.
 
*Belle JI, Langlais D, Petrov J, Pardo M, Jones RG, Gros P, Nijnik A. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1-deficiency. Blood. 2015.
 
*Pannu J, Belle J, Forster M, Duerr C, Kane L, Harcourt K, Fritz JH, Clare S, Nijnik A. Ubiquitin Specific Protease 21 is Dispensable for Normal Development, Hematopoiesis and Immunity. PLoS One 2015.
 
*Belle J, Nijnik A. H2A-DUBbing the Mammalian Epigenome: Expanding Frontiers for Histone H2A Deubiquitinating Enzymes in Cell Biology and Physiology. Int J Biochem Cell Biol. 2014.
 
*Nijnik A. Immunomodulatory approaches for prevention and treatment of infectious diseases. Curr Opin Microbiol. 2013.
 
*Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D, Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G. The Critical Role of Histone H2A-deubiquitinase MYSM1 in Hematopoiesis and Lymphocyte Differentiation. Blood. 2012.
 
Hancock RE, Nijnik A, Philpott D. Modulating immunity as a therapy for bacterial infections. Nature Reviews Microbiology. 2012.
 
Diehl AD, Augustine AD, Blake AJ, Cowell LG, Gold ES, Gondré-Lewis TA, Masci AM, Meehan TF, Morel PA, Nijnik A, Peters B, Pulendran B, Scheuermann RH, Zand MS, Mungall CJ. Hematopoietic Cell Types: Prototype for Revised Cell Ontology. J Biomed Inform. 2011.